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apalutamide will lessen the level or impact of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with prescription drugs that happen to be CYP3A4 substrates can result in decreased exposure to those drugs.Tend not to skip products Even wh